2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113756AR
    Latanoprost acid (Standard)
    		Inhibitor
    Latanoprost acid (Standard) is the analytical standard of Latanoprost acid. This product is intended for research and analytical applications. Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.
    Latanoprost acid (Standard)
  • HY-177440
    T26A
    		Inhibitor
    T26A is a competitive prostaglandin transporter (PGT) inhibitor (Ki=378 nM). T26A is promising for research of prostaglandin signaling and inflammatory diseases (e.g., glaucoma, pulmonary hypertension) .
    T26A
  • HY-116008
    8-iso Prostaglandin F3α
    8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA. Little is known about the biological activity of 8-iso PGF3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2α has an ED50 value of 1 μM.
    8-iso Prostaglandin F3α
  • HY-101642
    Losmiprofen
    		Inhibitor
    Losmiprofen is a nonsteroidal antiinflammatory agent.
    Losmiprofen
  • HY-101700
    LCB-2853
    		Antagonist
    LCB-2853 is an antagonist of thromboxane A2 (TXA2) receptor, with antiplatelet and antithrombotic activities.
    LCB-2853
  • HY-U00072
    RS-601
    		Antagonist
    RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.
    RS-601
  • HY-16768R
    Fevipiprant (Standard)
    		Antagonist
    Fevipiprant (Standard) is the analytical standard of Fevipiprant. This product is intended for research and analytical applications. Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an Kd value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma.
    Fevipiprant (Standard)
  • HY-17477R
    Guacetisal (Standard)
    		Inhibitor
    Guacetisal (Standard) is the analytical standard of Guacetisal. This product is intended for research and analytical applications. Guacetisal suppresses the synthesis of prostaglandin PG. Guacetisal is obtained from the esterification of acetylsalicylic acid with guaiacol which has the potential for chronic bronchitis treatment extracted from patent CN 106866420 A.
    Guacetisal (Standard)
  • HY-15853A
    MK-7246 S enantiomer
    		Antagonist
    MK-7246 S enantiomer is the less active enantiomer of MK-7246. MK-7246 is a potent and selective CRTH2 antagonist.
    MK-7246 S enantiomer
  • HY-112284A
    Ebopiprant hydrochloride
    		Antagonist
    Ebopiprant (OBE022) hydrochloride is an oral and selective prostaglandin F2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively.
    Ebopiprant hydrochloride
  • HY-100283
    CGS 15435
    		Inhibitor
    CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.
    CGS 15435
  • HY-W394717
    BGC-20-1531
    		Antagonist
    BGC-20-1531 (PGN 1531), a benzenesulfonamide derivative, is a selective EP4 antagonist. BGC-20-1531 binds to PGE2 enhancing the ATPase activity, which are coupled to Gs proteins and thus activate adenylate cyclase generating cAMP and activating PKA. BGC-20-1531 is promising for research of liver disorders.
    BGC-20-1531
  • HY-W701877
    Latanoprost tris(triethylsilyl) ether
    		Control
    Latanoprost tris(triethylsilyl) ether is a precursor in the synthesis of the prostaglandin F2α (PGF2α) receptor (FP receptor) agonist Latanoprost (HY-B0577).
    Latanoprost tris(triethylsilyl) ether
  • HY-125383
    ZK118182 Isopropyl ester
    		Agonist
    ZK118182 Isopropyl ester is the isopropyl ester analog of ZK118182, a prostaglandin analog.
    ZK118182 Isopropyl ester
  • HY-101840AR
    EIPA hydrochloride (Standard)
    		Inhibitor
    EIPA (hydrochloride) (Standard) is the analytical standard of EIPA (hydrochloride). This product is intended for research and analytical applications. EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.
    EIPA hydrochloride (Standard)
  • HY-106550
    Enprostil
    		Control
    Enprostil (RS 84135) is a prostaglandin E2 derivative. Enprostil can inhibit amogastrin-stimulated gastric acid secretion, as well as reducing the secretion of pepsin. Enprostil can also serve as an antiulcer agent, used for research of duodenal or gastric ulcers.
    Enprostil
  • HY-138206
    Prostaglandin E1 isopropyl ester
    		Activator
    Prostaglandin E1 isopropyl ester is an isopropyl ester form of prostaglandin E1 (HY-B0131). Prostaglandin E1 isopropyl ester exhibits a faster penetration flux than prostaglandin E1.
    Prostaglandin E1 isopropyl ester
  • HY-19518R
    Latanoprostene bunod (Standard)
    		Control
    Latanoprostene bunod (Standard) is the analytical standard of Latanoprostene bunod. This product is intended for research and analytical applications. Latanoprostene bunod (LBN), a nitric oxide (NO)-donating prostaglandin F2a analog, is a topical ophthalmic therapeutic for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT) .
    Latanoprostene bunod (Standard)
  • HY-10419A
    AH23848 hemicalcium salt
    		Inhibitor
    AH23848 hemicalcium salt is a potent, specific and orally active thromboxane receptor blocker. AH23848 hemicalcium salt inhibits platelet deposition.
    AH23848 hemicalcium salt
  • HY-118765
    Ro 23-3423
    Ro 23-3423 is a thromboxane synthase inhibitor with an IC50 value of 0.33 μM for human platelet microsomal thromboxane synthase. Ro 23-3423 increases plasma levels of PGF and PGE2 in a dose-dependent manner, accompanied by a decrease in mean systemic arterial pressure and systemic vascular resistance. Ro 23-3423 can be used in the study of general anesthesia.
    Ro 23-3423
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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